Air Marshal Amosu has held several Command and Staff appointments. These include, Safety Officer at 81 Air Maritime Group Benin, Wing Chief Operations Officer and Fleet Operations Officer both at the 101 Presidential Air Fleet, Abuja. Subsequently he became the Commander 101 Presidential Air Fleet. He was the Director of Operations, Headquarters Nigerian Air Force and later appointed Air Officer Commanding Tactical Air Command. He was appointed the 19th Chief of the Air Staff on 16 Jan 2014. Air Marshal Amosu is a seasoned pilot with over 6,200 flying hours on several Nigerian Air Force aircraft. Some of the aircraft flown include the Alpha-Jet, Dornier 128-6, Dornier 228, Falcon 900 and Gulfstream 5 airplanes