Recombinant human growth hormone (rhGH) replacement therapy
is a standard treatment option for promoting linear growth in growth
hormone-deficient (GHD) children. Growth hormone also has metabolic
effects on body composition, muscle strength, bone mineral density,
lipid profile, and endothelial function [1,2]. Impaired lipid metabolism
in GHD children may contribute to an increased risk of morbidity and
mortality due to cardiovascular disease [3,4].
Carotid intima-media thickness (CIMT) is a non-invasive predictive
indicator of atherosclerotic processes in the coronary arteries [5]. Altered
lipid profiles have been found to be associated with an increased
Recombinant human growth hormone (rhGH) replacement therapyis a standard treatment option for promoting linear growth in growthhormone-deficient (GHD) children. Growth hormone also has metaboliceffects on body composition, muscle strength, bone mineral density,lipid profile, and endothelial function [1,2]. Impaired lipid metabolismin GHD children may contribute to an increased risk of morbidity andmortality due to cardiovascular disease [3,4].Carotid intima-media thickness (CIMT) is a non-invasive predictiveindicator of atherosclerotic processes in the coronary arteries [5]. Alteredlipid profiles have been found to be associated with an increased
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