INTRODUCTION
Osteoarthritis (OA) is the most frequent painful musculoskeletal
disease (1), with a massive socioeconomic burden
(2). Because there is no cure, clinical management of OA is
an enormous challenge. The ultimate treatment is surgical
joint replacement, but conservative treatments are recommended
before surgery (3). A highly recommended treatment
for OA is exercise (4,5), with well-proven beneficial
effects on pain and disability (6). Although exercise is
more cost effective than surgery (5), the effect sizes of
exercise are moderate and optimization of the exercise
paradigm is needed.