This latter TDI was based upon reduced
body weight at 250 ppm in female rats in a 2-year drinking
water study (Beliles et al., 1985) and derived by dividing the NOAEL (125 ppm/7.7 mg/kg bw/d for males) by 1000. Health Canada
(1993) and RIVM (2001) derived a TDI of 120 lg/kg bw/d based
on the same NOAEL (125 ppm/12 mg/kg bw/d for females) but
using an AF of 100.