p53 transcriptionally regulates pro-apoptotic molecules,
such as BakHowever,p53 also inhibits Bcl-2 and Bcl-xL, which allows pro-apoptotic members
(Bak or Bax) to dissociate from heterodimeric complexes following the oligomerization of Bax and Bak into the mitochondrial outer membrane (MOM), which in turn forms lipid pores into the MOM through which the apoptotic initiators are released in response to death stimuli