is nonfluorescent and resistant to
intracellular esterases over a 2 h period, but Zn2+-mediated
hydrolysis of the acetyl groups reveals ZP1-TPP, which
localizes to mitochondria and has a 12-fold increase in
fluorescence intensity in response to Zn2+. Using this probe,
Chyan et al. were able to observe decreased mitochondrial Zn2+
uptake in cancerous prostate cells lines as compared to healthy
cells