Statistical Analysis
We calculated the phenotype frequencies by direct count. We
compared the frequency of each allele in the patient group as a
whole with the control population, using the chi-square test
followed by Fisher’s exact test. We estimated RR as recommended
by Svejgaard and colleagues (22). The haplotype frequency
was estimated with an equation derived from
Cavalli-Sforza and Bodmer’s research (23), and we used the chi-square test to calculate linkage disequilibrium (delta values)
for 2 locus models.
Results