Gastrointestinal ulcer could be induced by infection of the stomach by a bacterium called H. pylori, by chronic ingestion of NSAIDs, and exogenous substances such as cigarette, alcohol, and fast foods. A dietary natural drug (curcumin) could be used to protector treat the inflammation induced by the ulcer effectors. The biological effect of curcumin to combat these induced pathological disorders is due to its anti-inflammatory and antioxidant activities. Therefore, this review confirmed curcumin as an antiulcer potent agent.