An excellent question! "Game" refers both to the macabre game General Zaroff plays when he hunts humans and to the human prey that he regards as game just as he regards the animals he has killed as game. The "most dangerous game" then is one in which humans are hunted for at least two reasons: human life is at stake, and human game is dangerous because humans are the only species that can reason; therefore, humans pose a greater challenge for the hunter. In Zaroff's case, his game with Rainsford proves to be deadly for the hunter this time. The hunted outwits the hunter and manages not only to survive but to kill his pursuer. The game is over for Zaroff.