In MRSA, sea encodes SEA, which is a major virulence factor of S. aureus [12]. SEA induces staphylococcal gastroenteritis, secretion of T-cell-derived cytokines and T-cell activation because SEA possesses immunomodulatory properties of superantigens. The ethanol extract of A. princeps was observed to inhibit sea expression at concentrations higher than 1 mg/mL.