Objective: To evaluate the presence of insulin resistance and its association with other metabolic
abnormalities in obese children and adolescents.
Methods: Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric
measurements were performed (weight, height, and waist circumference) and clinical (gender,
age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol,
and fractions, triglycerides) data were analyzed. Insulin resistance was identified by the
homeostasis model assessment for insulin resistance (HOMA-IR) index. The analysis of the differences
between the variables of interest and the HOMA-IR quartiles was performed by ANOVA
or Kruskal-Wallis tests.
Results: Insulin resistance was diagnosed in 33.20% of the sample. It was associated with low
levels of high-density lipoprotein cholesterol (HDL-C; p = 0.044), waist circumference measurement
(p = 0.030), and the set of clinical and metabolic (p = 0.000) alterations. Insulin-resistant
individuals had higher mean age (p = 0.000), body mass index (BMI; p = 0.000), abdominal
circumference (p = 0.000), median triglycerides (p = 0.001), total cholesterol (p
≤
0.042), and
low-density lipoprotein cholesterol (LDL---C; p
≤
0.027); and lower HDL-C levels (p = 0.005).
There was an increase in mean BMI (p = 0.000), abdominal circumference (p = 0.000), and median
Objective: To evaluate the presence of insulin resistance and its association with other metabolicabnormalities in obese children and adolescents.Methods: Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometricmeasurements were performed (weight, height, and waist circumference) and clinical (gender,age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol,and fractions, triglycerides) data were analyzed. Insulin resistance was identified by thehomeostasis model assessment for insulin resistance (HOMA-IR) index. The analysis of the differencesbetween the variables of interest and the HOMA-IR quartiles was performed by ANOVAor Kruskal-Wallis tests.Results: Insulin resistance was diagnosed in 33.20% of the sample. It was associated with lowlevels of high-density lipoprotein cholesterol (HDL-C; p = 0.044), waist circumference measurement(p = 0.030), and the set of clinical and metabolic (p = 0.000) alterations. Insulin-resistantindividuals had higher mean age (p = 0.000), body mass index (BMI; p = 0.000), abdominalcircumference (p = 0.000), median triglycerides (p = 0.001), total cholesterol (p≤0.042), andlow-density lipoprotein cholesterol (LDL---C; p≤0.027); and lower HDL-C levels (p = 0.005).There was an increase in mean BMI (p = 0.000), abdominal circumference (p = 0.000), and median
การแปล กรุณารอสักครู่..
Objective: To evaluate the presence of insulin resistance and its association with other metabolic
abnormalities in obese children and adolescents.
Methods: Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric
measurements were performed (weight, height, and waist circumference) and clinical (gender,
age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol,
and fractions, triglycerides) data were analyzed. Insulin resistance was identified by the
homeostasis model assessment for insulin resistance (HOMA-IR) index. The analysis of the differences
between the variables of interest and the HOMA-IR quartiles was performed by ANOVA
or Kruskal-Wallis tests.
Results: Insulin resistance was diagnosed in 33.20% of the sample. It was associated with low
levels of high-density lipoprotein cholesterol (HDL-C; p = 0.044), waist circumference measurement
(p = 0.030), and the set of clinical and metabolic (p = 0.000) alterations. Insulin-resistant
individuals had higher mean age (p = 0.000), body mass index (BMI; p = 0.000), abdominal
circumference (p = 0.000), median triglycerides (p = 0.001), total cholesterol (p
≤
0.042), and
low-density lipoprotein cholesterol (LDL---C; p
≤
0.027); and lower HDL-C levels (p = 0.005).
There was an increase in mean BMI (p = 0.000), abdominal circumference (p = 0.000), and median
การแปล กรุณารอสักครู่..