To summarize, the present study revealed that repeated MPH
administration during periods corresponding childhood to early adulthood
may have an impact in the testis. This was observed by changes
in the volume of the interstitial tissue of the testicular parenchyma,
and in morphometric parameters, such testicle volumetric composition
and the cell population of germ cells of adult animals. The results could
be attributed to changes in the hypothalamic–pituitary–gonadal axis or
by direct action of MPH in male gonad.
These results reinforce the relevance of further investigation into the
mechanisms by which MPH may act on male germ cells