First, All urine samples were examined with strip rapid test then all urine extracts were screened with TLC analysis method. The results of urine strip test for drug abusers while they were under detoxification and treatment were positive although, these urine TLC results must be negative. So these results explain drug interaction, because abusers take some other medication under their physicians’ orders. All calculation were performed using SPSS.The data were analyzed by using of variance (ANOVA ONE WAY) by post hoc comparison between groups were examined with student Newman-kelus test. Differences in which p