omising agent which is increasingly used in
GCT is denosumab, a human monoclonal antibody against
RANK ligand, which is able to inhibit osteoclast function.
In 2010 Thomas et al. investigated its effect on tumor-cell
survival and tumor growth in patients with recurrent or
unresectable GCT and found that 86% had a tumor response
[45]. Although its effect has to be proven i