Anemia results from the body’s inability to maintain a level of erythropoiesis commensurate with hemolysis. The bone marrow compensates by producing large numbers of immature cell, such as normoblasts and erythroblasts, large cell that are extremely thin and form bizarre shapes, and target cell, which have abnormal staining properties. As a result of the excessive production of abnormal RBCs, their life span is severely shortened.