In conclusion, we have established a renal and hepatic injuries model of rats by CdCl2 subcutaneously treatment for studying the antagonistic and prophylactic effects of T. laurifolia Lindl. leaf extract. This study could not demonstrate that the leaf extract could not be used to treat Cd toxicity. However, the leaf extract may provide some protection if administrated prior to Cd exposure. The routes of the leaf extract administration to reduce Cd toxicity and/or the dosage of CdCl2 need to be modified in future