In two studies from
this laboratory, we demonstrated that resveratrol, via modulating
cyclin kinase inhibitor (cki)–cyclin–cyclin-dependent kinase (cdk)
network [15] and retinoblastoma (pRb)-E2F/DP machinery [14],
resulted in a G1-phase arrest of the cell cycle and apoptosis of human
epidermoid carcinoma (A431) cells. Another in vitro study
demonstrated that resveratrol was able to induce apoptosis in
two human melanoma cell lines