“Results” section, no adverse reactions related to GSSG were reported during the study period. Our clinical trial was conducted in the Philippines, which has a tropical climate. Subjects were advised to avoid applying sunscreen. However, the daily skin environment did not differ from that before the trial because the subjects were not in the habit of applying sunscreen. Nevertheless, the mechanism by which topical GSSG effectively whitens skin is not clear, and the relevance of GSH reduced from topical GSSG in the skin is no more than speculation. Furthermore, because there has been no other reported clinical trial of GSSG applica- tion, more studies will need to be accumulated in future to determine the safety of its long-term use.
“Results” section, no adverse reactions related to GSSG were reported during the study period. Our clinical trial was conducted in the Philippines, which has a tropical climate. Subjects were advised to avoid applying sunscreen. However, the daily skin environment did not differ from that before the trial because the subjects were not in the habit of applying sunscreen. Nevertheless, the mechanism by which topical GSSG effectively whitens skin is not clear, and the relevance of GSH reduced from topical GSSG in the skin is no more than speculation. Furthermore, because there has been no other reported clinical trial of GSSG applica- tion, more studies will need to be accumulated in future to determine the safety of its long-term use.
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