Two-component regulation is ubiquitous within the prokaryotic domain,
with the numbers of two component proteins varying among bacteria from only a few to
over 250 proteins (E. coli has and 29 sensor kinases and 32 response regulators) [18]. Our
study shows that the introduction of a foreign response regulator gene into E. coli can directly
impact gene expression, leading to an antibiotic resistance phenotype.
Metagenomic Response Regulator Confers Antibiotic Resistance