Pesticides are major components of the modern agricultural production because of their high capability and reliability for crop protection against pests and assurance of high crop yields. Approximately 5 billion kg of pesticides are applied worldwide per year, which can have serious effects on non-target organisms, food chain and biodiversity, posing high risks to the environment and human health. In rural areas of developing countries, three million farmers suffer annually from serious pesticide poisoning and 25 million farmers suffer from mild poisoning, resulting in approximately 180,000 fatalities among agricultural workers annually, because of incorrect perceptions, lack of knowledge, regulation, and education among farmers. Approximately 23% of Indian farmers, 25% of Mexican farmers and 43% of Zimbabwean farmers have been reported to suffer from work-related pesticide poisoning.