Generally, the ethanol extracts proved to be more potent
than the methanol extracts and supercritical CO2 extracts as shown by their lower MICs for
both the Grampositive and Gram negative MDRs. MTT cytotoxicity assay showed that the
highest concentration (100 μg/ml) of P. betle ethanol extract tested was not toxic to normal
human dermal fibroblasts (HDFn). Data from the study firmly established P. betle as an alternative
source of anti-infectives against multiple drug resistant bacteria.