The expression of melanocyte specific genes, Tyr, Tyrp1, and Mc1r, was evaluated in Melan-a cells treated for 24 h
with chia seed and pomegranate fruit extracts, alone and in combination, relative to untreated control cells.
Ascorbic acid-2-glucoside, an ascorbic acid derivative known to prevent skin pigmentation through suppression of melanin
synthesis in melanocytes, was used as a positive control.