Approximately 0.4 mL of neat 5-FU (50 mg/mL)
(33,34) and 20 IU botulinum toxin (50 IU/mL) were infiltrated alternately
per cm of wound tissue, with the total dose injected kept below
500 mg and 140 IU, respectively. The wound was painted with 5%
lidocaine prilocaine cream (Emla, Astra, Sweden) 45 min before the
injection to achieve local anaesthesia. Laboratory tests, before or after