In a “structural” perspective, Kreth and colleagues modeled theextent of radiation induced chromosome damage under certaingeometrical constraints and compared it to experimental data inorder to make the distinction between various competing mod-els: namely territorial and non-territorial models (Kreth et al.,1998). For this, localized irradiation with a focused UV-laser beam( = 257 nm) was conducted and simulated, considering that if thechromosome arrangement in interphase was a non-territorial one,more chromosomes would be damaged by the localized irradiationthan in case of a territorial organization. The difference was obviousand discredited non-territorial models.