This study is referred from the vision and policy of the Basic Education Core Curriculum B.E. 2551 (A.D. 2008) to improve learning as student-centered to administer of the Problem-based learning (PBL) and modernizing instructional method of the STEM are to approach that challenges students to learn through engagement in the real problems solving strategies and disciplinary knowledge bases and skills by placing students in the active roles. These instructional process were to design of the 5-innovation lesson plan with sample size of 80 students in two classes at the ninth grade level in Wapiphatum School for teaching in each science class, the controlling class was administered with the Problem-based learning (PBL) lesson plans and experimental group was designed teaching plans of the 5-STEM instructional lesson plans. Students’ learning activities and outcomes were assessed with the Pretest and Posttest techniques, their responses of their science class were assessed with the My Class Inventory (MCI) is a questionnaire that simultaneously develops both problem solving strategies and disciplinary knowledge bases and skills by placing students’ classroom environments. Students’ associations between their perceptions of their science classes with their science attitudes were predicted with the Attitude Scale. The findings of this study were indicated that students’ learning achievements of posttest scores showed higher than pretest, significant differently. Students’ outcomes of the controlling and experimental groups also were found, similarly. Associations between students’ performances of their each instructional class and their attitudes toward science were related to their likely face as future managers in complex organizations. Suggestions that the Problem-Based Learning ought to student-centered and makes a fundamental teaching to a focus on learning, STEM’s recommendations of the skills of teachers through additional training in science, mathematics and technology to be motivated of students’ science skills and science attitudes, increasingly.