Processed foods are often perceived as having negative attributes, including limited nutritional value, high calorie content, increased glycemic index, and excessive amounts of sugar, salt, chemical preservatives, and/or oil. Extrusion is a technology that is widely used for processing ready-to-eat snack and breakfast cereal products. Use of fruit and vegetable by-products to improve the nutritional profile of extruded foods by delivering both fiber and antioxidants is described. In the samples tested, extrusion led to a decrease in the concentration of antioxidants (phenolic compounds and carotenoids) in expanded products containing apple and tomato pomaces. However, the free-radical scavenging capacity (antioxidant activity) increased due to processing, underscoring the potential health benefits of incorporating these ingredients.