Numerous synthetic and highly active forms of GnRH
have been developed principally for clinical use in human
and veterinary medicine, and some long-acting formulation
have been used in some fish species. We considered
des-Gly-His-(Bzl)-GnRH-ethylamide and des-Gly10, DAla6,
Pro-GnRH the most promising because they have
been shown to be biologically active in frogs ([12,18,38-
40]. Similarly, among the numerous DA antagonists on
the market, pimozide has been used successfully in fish
[41] and metaclopromide is active in R. temporaria [32].
Preliminary experiments on a limited number of animals
(Lithobates pipiens and Ceratophrys ornata, data not
shown) and doses reported in the literature were used to
establish the compounds and doses used.
Numerous synthetic and highly active forms of GnRHhave been developed principally for clinical use in humanand veterinary medicine, and some long-acting formulationhave been used in some fish species. We considereddes-Gly-His-(Bzl)-GnRH-ethylamide and des-Gly10, DAla6,Pro-GnRH the most promising because they havebeen shown to be biologically active in frogs ([12,18,38-40]. Similarly, among the numerous DA antagonists onthe market, pimozide has been used successfully in fish[41] and metaclopromide is active in R. temporaria [32].Preliminary experiments on a limited number of animals(Lithobates pipiens and Ceratophrys ornata, data notshown) and doses reported in the literature were used toestablish the compounds and doses used.
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