Acute toxicity
According to the Organization of Economic Co-operation
and Development (OECD) guideline for testing of chemicals,
TG420 (OECD, 2001a), 10 rats were randomly divided into two
groups of five animals per sex. The EJ-ext at a single dose of
5000 mg/kg body weight was given orally to treated group, the
control group recieved vehicle. Body weight, signs of toxicity
and mortality were observed after the administration at the first,
second, fourth and sixth hour and once daily for 14 days. On
the day 15, all rats were fasted for 16–18 h, then sacrificed for
necropsy examination. The internal organs were excised and
weighed. The gross pathological observations of the tissues were
performed.