Photoprotection against erythema has been previously
reported by combination vitamins C and E
administered systemically58,59 or applied topically to
skin.47,60 This combination was particularly effective
at preventing the tanning response and immunosuppression
of contact hypersensitivity.61 Because -tocopherol
is the major antioxidant of the outer layers
of skin, its lipophilic nature lends itself to topical
application; absorption occurs in minutes.39 Simultaneous
application of L-ascorbic acid may be an
advantage because it adds a coantioxidant to the
outer layers of skin. It may then be available to
regenerate -tocopherol whenever it is oxidized,
regenerating it for further protection.