Allicin improved cardiac dysfunction in diabetic rats
As shown in Table 1, there were no significant differences in
weight and blood glucose among the six groups at the beginning of
this research. However, after 4 weeks, blood glucose levels in ALtreated
groups (8 mg/kg and 16 mg/kg) and MET (100 mg/kg) group
were significantly higher than before STZ treatments (p < 0.01), but
dramatically lower than those in the model group (p < 0.01). Similarly,
the hemodynamics parameters were also observed among
the six groups (Table 2). After the treatment of AL (4 mg/kg, 8 mg/kg
and 16 mg/kg) and MET (100 mg/kg), LVSP, LVEDP, and
±dp/dtmax
were measured as indices of cardiac function, which were significantly
higher in LVSP and +dp/dtmax and lower in LVEDP compared
with model group. Therefore, the improvement in cardiac dysfunction
and the decrease in blood glucose were clearly observed in
AL-treated diabetic rats compared with untreated diabetic rats in a
dose-dependent manner.