The lab of Kristen Lynch, PhD, a professor of in the departments of Biochemistry & Biophysics and Genetics, at the Perelman School of Medicine at the University of Pennsylvania, studies how this splicing occurs in T cells and how it is regulated by multiple proteins. A new study published in the Proceedings of the National Academy of Sciences from her lab describes a cascade of events that may explain changes in gene expression that occur during the development of the human immune system.