These symptoms may be accompanied by loss of appetite, vomiting, irritability, continuous crying, and seizures. As the disorder progresses, symptoms may also include generalized weakness, lack of muscle tone, and episodes of lactic acidosis, which can lead to impairment of respiratory and kidney function.
Affected infants may fail to grow and gain weight at the expected rate (failure to thrive).
. Delays in reaching developmental milestones may also occur