Effect of CCl4 on plasma coagulation-factor levels
In WT mice, the plasma levels of most coagulation factors significantly decreased 24 h post-CCl4 injection, fibrinogen, prothrombin, and factors V, VII, IX, and X. How- ever, the plasma levels of FVIII:C and VWF antigen signifi- cantly increased following injection (Fig. 3). Injection of the same CCl4 dose into hemophilia A mice caused death within 24 h in five of 16 hemophilia A mice, whereas no hemophilia A mice died after administration with the same volume of vehicle control (n = 6). WT mice (n = 16) showed no mortality under the same conditions.