The laboratory diagnosis of cryptococcosis is established by the isolation of the organism in culture, histopathology, or detection of its polysaccharide capsular antigen [12]. The present case was also diagnosed by culture, India ink and latex agglutination test. The organism grows in blood and chocolate agar within 3 to 5 days. Analysis of CSF usually reveals a poor white blood cell (WBC) count, with normal or low CSF glucose levels, and a positive cryptococcal antigen test. The India ink test is more specific and helps in demonstrating the fungus [13].