Numerous factors may affect the extent of the impact of MA use on cognition; for example,
younger age at first MA use may be an important factor, as research indicates exposure to
substances in childhood or adolescence produces long-lasting changes in cognition.1 Scott et
al.11 report that the neurocognitive effects of MA may potentially be explained by factors
including demographics (e.g., gender), characteristics such as duration of MA abstinence,
and the influence of common psychiatric and neuro-medical comorbidities such as HIV
infection. The study found that gender had a relatively minor, but significant, influence on
the magnitude of the MA-associated effect sizes, in that a larger proportion of men in a MA
sample was associated with greater overall levels of neuropsychological impairment.
Normal aging is associated with structural and functional changes in prefrontal systems,12
which may lead to additive cognitive deficits in an aging population of MA users.13 Scott et
al.11 report that neither education nor the between-group discrepancy in education had a
significant influence on the effect size estimates, and the length of MA use was also not
correlated with the magnitude of effect.
Numerous factors may affect the extent of the impact of MA use on cognition; for example,younger age at first MA use may be an important factor, as research indicates exposure tosubstances in childhood or adolescence produces long-lasting changes in cognition.1 Scott etal.11 report that the neurocognitive effects of MA may potentially be explained by factorsincluding demographics (e.g., gender), characteristics such as duration of MA abstinence,and the influence of common psychiatric and neuro-medical comorbidities such as HIVinfection. The study found that gender had a relatively minor, but significant, influence onthe magnitude of the MA-associated effect sizes, in that a larger proportion of men in a MAsample was associated with greater overall levels of neuropsychological impairment.Normal aging is associated with structural and functional changes in prefrontal systems,12which may lead to additive cognitive deficits in an aging population of MA users.13 Scott etal.11 report that neither education nor the between-group discrepancy in education had asignificant influence on the effect size estimates, and the length of MA use was also notcorrelated with the magnitude of effect.
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