Additional features that may be associated with greater risk of new-onset T2DM, as already mentioned, are familial history of diabetes mellitus, female gender, older age (especially with high-dose statins), Asian ethnicity, duration of statin treatment. Other associated factors possibly leading to enhance new-onset T2DM risk are related to concomitant drug treatment. In the NAVIGATOR Study, evaluating the effect of valsartan and nateglinide on the conversion to T2DM in patients with impaired glucose tolerance and other cardiovascular risk factors over a 5-year follow-up, the concomi- tant use of diuretics and statins was associated with a significantly increased risk of new-onset T2DM. No effect of beta-blockers or calcium-channel blockers was observed [40].