Bothrops jararacussu and Bothrops jararaca venoms induced the
release of the Azo group from the substrate(Azocolls), increasing
the absorbance in a concentration-dependent way(data not
shown).The incubation of 50 mg/mL of the venoms with Combretum
leprosum extract(1–300 μg/mL, Fig.7C) and arjunolic acid(0.1–
100 μg/mL, Fig.7D) antagonized their collagenase activity in a
concentration-dependent way. Combretum leprosum extract(300
μg/mL)reduced the Bothrops jararaca and Bothrops jararacussu
collagenase activities down to approximately 2579% and 271%,
respectively,whil earjunolic acid (100 μg/mL) reduced their activities down to 4479% and to 3977%,respectively.