Glass-ceramics are defined as composite materials constituted of crystals in a glassy matrix. This combination between amorphous and crystalline states leads to a new type of material having unique properties that can be adjusted. Chalcogenide glass-ceramics are a recent target of research and appear very promising to make more efficient materials for passive and active applications working from the visible to the mid-infrared ranges. In this chapter, the theoretical and practical ways to make reproducible glass-ceramics containing nanoparticles will be described. Their efficiency in making materials with improved mechanical properties or with exacerbated nonlinear or luminescence phenomena will be described.