One recurring rearrangement in T-cell neoplasia is a
paracentric inversion of chromosome 14 with a proximal
breakpoint at q1l and a distal breakpoint at q32 (11-13). A
closely related rearrangement, t(14;14)(qll;q32), is seen in
T-cell neoplasia (14, 15) and in phytohemagglutinin-stimulated
lymphocytes from patients with ataxia-telangiectasia as
well as in the leukemic cells of those patients in whom this
disease evolved (13). Also, Williams et al. (16) have described
a t(11;14)(p13;q13) in the leukemic cells of 4 of 16
patients with T-cell acute lymphoblastic leukemia.