The pathomechanism of AFE was explained based on three known theories and the unified concept of AFE has been published recently [4,5]. However, AFE still remains medical enigma, since many issues are unexplained. It is still unclear why AFE, which is usually typical, having three clinical phases with cardiopulmonary collapse as initial presentation, can also have an atypical course (initial presentation can be the disseminated intravascular coagulation-DIC-with or without hemorrhage as well as only isolated DIC or/and Acute Respiratory Distress Syndrome, ARDS)