A cross-sectional survey of 200 adolescents aged 15 to 18 years used two health-related quality of life questionnaires: the Children’s Dermatology Life Quality Index© (CDLQI) and the Cardiff Acne Disability Index© (CADI) [6]. Acne was reported in 83 percent of teenagers, 54 percent of males and 46 percent of females. The overall CDLQI score ranged from 0 to 19 out of a maximum 30, with a mean of 1.7 (CI -1 to 0), representing approximately 6 percent impairment. Nine subjects scored between 5 and 9, suggesting moderate (17 to 30%) impairment, whereas three scored greater than 10, suggesting severe (> 33%) impairment. Similarly, the overall CADI score ranged from 0 to 15 out of 15, with a mean of 1.9 (CI 0 to 1), representing 13 percent impairment. Twelve subjects scored between 5 and 9 (33–60% impairment), one scored 10+ (> 67% impairment), and one scored the maximum, 15 (100% impairment). There was no significant difference in mean scores between sexes for either questionnaire. The authors concluded that acne significantly impacts QOL in some teens.