In November 1990, the Czech government initiated program to improve the ecological situation in the mining districts of Northern Bohemia. In this regard, the district of Teplice was recommended as a model district for a newly established research program: Impact of Air Pollution on Human Health (Teplice Program). The district of Prachatice, a significantly less polluted region in Southern Bohemia, was chosen as a control district (Fig. 1) (Sram et al., 1996).