Multiple mechanisms are at play
including upregulation of tissue factor leading to the initiation
of clotting, amplification of the clotting process by
augmenting exposure of cellular coagulant phospholipids,
inhibition of fibrinolysis by elevating plasminogen activator
inhibitor1 and decreases in natural anticoagulant pathways,
leading to downregulation of the protein C anticoagulant
pathway