How does Arcoxia work?
Note: Arcoxia has not been approved by the FDA for the U.S. market.
Arcoxia belongs to a group of medicines called cyclooxygenase-2 (COX-2) specific inhibitors (also known as coxibs).
The body produces two similar enzymes called COX-1 and COX-2. COX-1, among other functions, is involved with protecting the stomach, while COX-2 plays a role in joint inflammation and pain.
Arcoxia reduces pain and inflammation by blocking COX-2, an enzyme in the body.
Arcoxia does not block COX-1, the enzyme involved in protecting the stomach from ulcers.
Other anti-inflammatory medicines (NSAIDS) block both COX-1 and COX-2.
Arcoxia relieves pain and inflammation with less risk of stomach ulcers compared to NSAIDS.
However taking aspirin with Arcoxia may reverse this benefit (see Before you take Arcoxia, Taking Other Medicines).
In clinical studies, the risk of developing ulcers on Arcoxia was lower than with NSAIDs. Some people developed ulcers whether they were taking Arcoxia or placebo in these studies; however the rate was higher on Arcoxia.
If any of the following symptoms: shortness of breath, chest pains or ankle swelling appear or worsen, stop your treatment with Arcoxia and consult a doctor, as soon as is practical.
If you have kidney, liver or heart disease, your doctor will want to appropriately keep a check on you.
If you develop any symptoms that could indicate a severe allergic reaction such as an inability to breathe or a serious skin reaction you must consult a doctor on an urgent basis.