Conclusions
In conclusion, E2V/DNG has a consistent, significant positiveimpactonworkproductivityandactivitiesofdailyliving in U.S. and Canadian women with HMB. In addition, these improvements in work productivity and activities of daily living were associated with a reduction in HMB-related monetary burden compared to the placebo group. Observational studies in women with self-reported HMB (as opposed to clinical trials assessing HMB confirmed with objective measures) are needed to confirm our finding in the real-world setting.