tensile property and in vitrobiodegradation behavior guaranteed the FCA/COS scaffolds for skin tissue engineering application. Fur-ther improvement of these properties enhanced the cytocompatibility of all the scaffolds, especially thescaffolds containing COSs with MW in the range of 1–3 kDa (FCA/COS1) showed the best cytocompati-bility. These physicochemical, mechanical, and biological properties suggest that the FCA/COS1 scaffoldis a superior candidate that can be used for skin tissue regeneration