For many pathogens, intracellular survival is critical to their
pathogenicity, because it provides a basis for dissemination and
latency. Intracellular pathogens are able to spread within the body,
triggering little or no effective immune response from the host.
Moreover, many pathogens use the host cell as a nutrient source to
support rapid replication, thus acting as genuine intracellular
parasites (1, 2). The human fungal pathogen Cryptococcus is an
intracellular parasite of macrophages (3, 4) and is believed to
exploit these host cells to traffic from the lung, the primary site of
infection, into the central nervous system (5, 6).
For many pathogens, intracellular survival is critical to theirpathogenicity, because it provides a basis for dissemination andlatency. Intracellular pathogens are able to spread within the body,triggering little or no effective immune response from the host.Moreover, many pathogens use the host cell as a nutrient source tosupport rapid replication, thus acting as genuine intracellularparasites (1, 2). The human fungal pathogen Cryptococcus is anintracellular parasite of macrophages (3, 4) and is believed toexploit these host cells to traffic from the lung, the primary site ofinfection, into the central nervous system (5, 6).
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