considered to be
the reservoir for MERS-CoV, develop a mild upper respiratory tract infection with abundant viral shedding.
Although normal mice are not susceptible to MERS-CoV, expression of the human DPP4 (hDPP4)
overcomes the lack of susceptibility. Transgenic hDPP4 mice develop severe and lethal respiratory disease
upon inoculation with MERS-CoV.