Previous studies examining the bivariate relation of health behavior focused on only one factor, either dis-ease knowledge or self-efficacy, rather than analyzing the concomitant effects of associated factors on health behaviors. In addition, they are mostly performed in western countries. Methodologically, most studies utilized a general scale in measuring disease knowl-edge and self-efficacy.This fact may interfere with the appropriate representation of the variables measured. Therefore, under the consideration of cultural char-acteristic, the two factors (disease knowledge and self-efficacy) should be examined in terms of their association with health behaviors in CADs patients. Additionally, in measuring disease knowledge and self-efficacy, cardiac specific instruments should be employed such as cardiac knowledge and cardiac self-efficacy.