novel therapeutics. One area not covered in this review is the genetic relationship between personality and other traits in the general population and schizophrenia risk. This is because there are as of yet no adequately powered GWAS of such traits, which is an unmet research need. In the decade to come, the RDoC initiative will undoubtedly increase the number of studies addressing issues of the diagnosis and classification of schizophrenia, whether directly or indirectly. It is hoped that this will provide a stronger empirical and biological basis for the development of DSM-6 as was available to benefit DSM-5.